Endocrine Abstracts

Autoimmune adrenal insufficiency (AAI) is a classic organ-specific autoimmune disease caused by immune-mediated destruction of steroidogenic cells in the adrenal cortex. Autoreactive T cells and autoantibodies targeting the steroidogenic cytochrome P450 enzyme 21-hydroxylase (21OH) are present in the majority of patients. AAI can appear isolated or as part of two forms of autoimmune polyendocrine syndromes, the rare monogeneic autoimmune polyendocrine syndrome type 1 (APS-1) a...